Abzena published an article outlining where ADCs and AOCs diverge, including OAR tolerance, charge density, maleimide-thiol linkages, and cleavable vs. non-cleavable linkers.

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ADCs and AOCs share the same basic architecture, an antibody, linker, and a payload. But assuming AOC linker design is just an ADC with a different payload can be a cost…

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Company

Abzena

Abzena is the leading integrated bioconjugate & complex biologics CDMO+CRO, focused on rapidly moving medicines forward.

Industry
Pharmaceutical Manufacturing
Location
San Diego, US
Company size
201–500 employees

About Abzena

Abzena is the leading end-to-end bioconjugate, ADC, and complex biologics CDMO + CRO. From discovery through commercial launch, we support customers with fully integrated programs or individual services designed to de-risk and streamline the development of new treatments for patients in need. With the ability to tailor its strategy and customer experience to each project, Abzena develops and implements innovative solutions that enable biotech and biopharma companies to realize the full potential of their molecule and move medicines forward faster. The company has research, development, and cGMP facilities across locations in San Diego, CA, Bristol, PA, and Cambridge, UK.

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