ACIR published research by Chen, Pulido, et al. investigating how AIRE expression in tumor cells impacts antitumor immune responses using murine models.
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Role of AIRE in tumors https://bit.ly/4gPblQ0 Chen, Pulido, et al. investigated how AIRE expression in tumor cells impacts antitumor immune responses using murine models…
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ACIR
We prepare a weekly digest on the latest and most promising findings in cancer immunotherapy, free-of-charge.
- Industry
- Writing and Editing
- Location
- Concord, US
- Company size
- 11–50 employees
About ACIR
ACIR’s mission is to accelerate cancer immunotherapy research by preparing a free-of-charge weekly synopsis of the key advances in this fast-moving and multifaceted field. Our scientists scour PubMed and curate the key publications we believe all researchers should be aware of. We also make some cool cartoons :) We hope that by making it easier to stay up to date, our summary will enhance the productivity and creativity of many, bringing us closer to a cure.
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ACIR published research by Chen, Pulido, et al. showing that overexpression of AIRE leads to higher expression of self-proteins, MHC-I in the context of H-2Kb, and MHC-I-presented epitopes, whereas downregulation leads to lower expression.
Research & Knowledge
ACIR published research by Chen, Pulido, et al. showing that in vivo delivery of an AAV vector can induce therapeutic AIRE tumor expression and improve survival time by subsequent ICB.
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