GORYO CHEMICAL, INC published a study in Cell Metabolism showing that colorectal cancer cells use an adaptive metabolic program to buffer iron-driven oxidative stress.

GORYO Chemical, Inc. provides new fluorescent probes for cellular analysis, assay, and imaging. AcidiFluor™ ORANGE is a fluorescence imaging probe which enhances fluorescence dramatically in acidic environments. This probe can selectively stain acidic organelles such as lysosome, late endosomes and granules. Its has excellent selectivity enabling it to detect acidic environments. At pH 5.0, identical to the environment of acidic organelles, the fluorescence intensity is 50-fold or more compared to pH 7.4. AcidiFluor™ ORANGE shows excellent photostability to excitation light. CaSiR-1™ and CaSiR-1™ AM are near-infrared fluorescence calcium probes which have fluorescence maximum wavelength at 664 nm. Multicolor imaging is possible between CaSiR-1™ or CaSiR-1™ AM and fluorescent probes or fluorescent proteins which have fluorescent wavelength in visible range such as Hoechst, Fluorescein, Rhodamine, GFP, YFP and RFP etc. The near-infrared region has greater tissue penetration, less overlap with the spectrum of background autofluorescence and exhibits less phototoxicity to cells and tissue. GlycoYELLOW™-βGal is a specific fluorescent probe for detection of β-galactosidase. It can be used in fluorescent imaging and identification of cells and tissue transfected with lacZ. Because GlycoYELLOW™-βGal is almost non-fluorescent in the absence of β-galactosidase, this probe exhibits an excellent S/N ratio.