Helix Biostructures published a review highlighting how cryo-EM transformed NADPH oxidase biology, including resting and activated NOX2-p22phox structures, calcium-driven NOX5 rearrangements, and integration with AlphaFold and molecular dynamics.
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Obtaining protein complexes in both resting and activated states is especially valuable because it reveals activation-linked structural changes, although flexible and dy…
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Helix Biostructures
A structural biology CRO providing structure-based drug discovery services to biotech & pharmaceutical clients.
- Industry
- Research Services
- Location
- Indianapolis, US
- Company size
- 11–50 employees
About Helix Biostructures
Helix Biostructures, LLC (HBS) is a structural biology CRO (Indianapolis, IN) providing structure-based drug design services to early-stage through Fortune 500 drug discovery companies. HBS provides gene-to-structure services ranging from expression & purification of structural biology grade protein to X-ray Crystallography (Crystallization & X-ray Data Collection), Bio-SAXS, Cryo-EM, and Micro-ED. HBS also provides Biophysical Characterization methods such as ITC, SPR, and Mass Spec. (ESI-MS, Peptide fingerprinting, & Gel band analysis).
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