Spectradyne ran the same EV reference material through four conditions: alone, spiked into serum, immunolabeled in serum, and an immunolabeled serum-only control without ever purifying the mixture.

Spectradyne's particle analysis technology is rapidly being adopted as a powerful and significantly more accurate alternative to light scattering-based methods of particle analysis. The technology is fast and easy to use, and accurately measures the concentration, size and fluorescence of particles from 50 nanometers to 10 microns in diameter in a liquid, using a disposable microfluidic cartridge. Spectradyne's patented technology uses Microfluidic Resistive Pulse Sensing (MRPS) to count and size particles one-by-one electrically—not optically. MRPS is a modern implementation of a technique commonly referred to as Coulter counting that has long served as the gold standard for quantifying larger microparticles and cells. Spectradyne’s new microfluidic implementation enables unparalleled strengths: Complex biological samples such as plasma and cell culture media can be analyzed directly and total analysis of a sample requires only 3 microliters, enabling completely new science to be realized. Scientists around the world use MRPS in a broad range of life science application areas including extracellular vesicle (EV) research, gene therapy and nanomedicine, virus and phage quantification, formulation development & stability, vaccine development, liposomes, lipid nanoparticles. MRPS is also used to quantify industrial materials such as polymeric nanoparticles, CMP slurry, paints, inks, foods, floor finish, magnetic beads and coatings, and other inorganic materials. Interested in learning how our technology can help your science? Spectradyne demonstrates the power of its technology to researchers by measuring a few samples for free—visit us at www.nanoparticleanalyzer.com to learn more.