Company intelligence
PCL Research&Manufacturing srl
From the Right Molecule to the Right Particle
About PCL Research&Manufacturing srl
PCL Research&Manufacturing is a privately owned company service provider, leader in contract research, development, and manufacturing (CRO/CDMO). Equipped with state-of-the-art analytical instruments ,our laboratories operate to the highest standards and in GMP compliance. Thanks to our extensive experience in solid state and crystallization chemistry we provide integrated services, and technologies satisfying our worldwide clients from more than 20 years. What makes us different ? Efficiency - Working closely with our clients allows us to tailor each project optimizing time and leading to successful results. Reliability - We are committed to continual improvement based on sound science and the use of modern technologies with high safety standards (handling Highly potent API up to OEB5) providing clear and trustful results. Expertise - Highly trained team of chemists and analysts with more than 20 years of experience in the discovery of new solid forms and in the development and optimization of crystallisation processes.
Verified activity
Signals from PCL Research&Manufacturing srl
10 published signals
Research & Knowledge
PCL Research&Manufacturing srl used real-time Process Analytical Technology tools including Focused Beam Reflectance Measurement and in-situ Raman spectroscopy to monitor chord length distribution and supersaturation live during seeding.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl optimized the seeding temperature and introduced a controlled cooling profile to direct crystal growth within the metastable zone and eliminate spontaneous nucleation.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl optimized the crystallization process to produce uniform, equidimensional crystals that improved filtration speed by 350% and provided batch-to-batch particle size distribution reproducibility at scale.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl applied Quality by Design principles to systematically map the Metastable Zone Width as a function of cooling rate, solvent composition, and agitation energy in a crystallization development project.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl constructed a comprehensive thermodynamic and kinetic phase energy landscape using high-throughput screening, automated cooling, solvent-evaporation, and slurry crystallization protocols to evaluate polymorphic space for small-molecule active pharmaceutical ingredients.
Reported by Stefano Luca Giaffreda
Presence & Recognition
PCL Research&Manufacturing srl is hosting a 1-on-1 consultation at CPHI 2026 in Milan to discuss solid-state strategy for candidate pipelines.
Reported by Stefano Luca Giaffreda
Products & Services
PCL Research&Manufacturing srl introduced CrystallQ, a proprietary AI-driven crystal form prediction platform designed to transform drug substance de-risking.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl identified that the root cause of unstable solid forms in an ionizable basic API was a failure to rigorously evaluate the ionization continuum between the drug molecule and its potential counterions.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl offers niche expertise in crystal engineering through advanced screening and custom-tailored crystallization experiments.
Reported by Stefano Luca Giaffreda
Research & Knowledge
PCL Research&Manufacturing srl highlighted that screening and scale-up scientists work side by side on the same molecule from day one to batch release.
Reported by Stefano Luca Giaffreda