PCL Research&Manufacturing srl is hosting a 1-on-1 consultation at CPHI 2026 in Milan to discuss solid-state strategy for candidate pipelines.
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Over 50% of small-molecule active pharmaceutical ingredients (APIs) exhibit polymorphism, where distinct crystalline packing arrangements lead to drastic variations in s…
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PCL Research&Manufacturing srl
From the Right Molecule to the Right Particle
- Industry
- Pharmaceutical Manufacturing
- Location
- Medicina, IT
- Company size
- 11–50 employees
About PCL Research&Manufacturing srl
PCL Research&Manufacturing is a privately owned company service provider, leader in contract research, development, and manufacturing (CRO/CDMO). Equipped with state-of-the-art analytical instruments ,our laboratories operate to the highest standards and in GMP compliance. Thanks to our extensive experience in solid state and crystallization chemistry we provide integrated services, and technologies satisfying our worldwide clients from more than 20 years. What makes us different ? Efficiency - Working closely with our clients allows us to tailor each project optimizing time and leading to successful results. Reliability - We are committed to continual improvement based on sound science and the use of modern technologies with high safety standards (handling Highly potent API up to OEB5) providing clear and trustful results. Expertise - Highly trained team of chemists and analysts with more than 20 years of experience in the discovery of new solid forms and in the development and optimization of crystallisation processes.
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Latest activity from PCL Research&Manufacturing srl
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Research & Knowledge
PCL Research&Manufacturing srl used real-time Process Analytical Technology tools including Focused Beam Reflectance Measurement and in-situ Raman spectroscopy to monitor chord length distribution and supersaturation live during seeding.
Research & Knowledge
PCL Research&Manufacturing srl optimized the seeding temperature and introduced a controlled cooling profile to direct crystal growth within the metastable zone and eliminate spontaneous nucleation.
Research & Knowledge
PCL Research&Manufacturing srl optimized the crystallization process to produce uniform, equidimensional crystals that improved filtration speed by 350% and provided batch-to-batch particle size distribution reproducibility at scale.
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